Welcome to UTRdb
The 5' and 3' untranslated regions of eukaryotic mRNAs play crucial roles in the posttranscriptional regulation of gene expression through the modulation of nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and message stability. UTRdb is a curated database of 5' and 3' untranslated sequences of eukaryotic mRNAs, derived from several sources of primary data. Experimentally validated functional motifs are annotated and also collated as the UTRsite database where more specific information on the functional motifs and cross-links to interacting regulatory protein are provided. In the current update the UTR entries have been organized in a gene-centric structure to better visualize and retrieve 5' and 3'UTR variants generated by alternative initiation and termination of transcription and alternative splicing. Experimentally validated miRNA targets and conserved sequence elements are also annotated. The integration of UTRdb with genomic data has allowed the implementation of an efficient annotation system and a powerful retrieval resource for the selection and extraction of specific UTR subsets.
UTRef contains a total of 473,330 5'UTR and 527,323 3'UTR entries, respectively, from 483,605 genes in 79 species. A total of 788,370 UTRsite motifs are annotated (317,767 in the 5'UTRs and 470,603 in the 3'UTRs), 20,191 experimentally validated miRNA targets, and 242,773 conserved regions.
For human, the UTRfull section is also available, including UTRs deriving from full length transcripts collected in ASPicDB. Overall, UTRfull contains 124,345 and 194,503 5' and 3' UTRs respectively (3.37/gene) and 3'UTRs (5.18/gene), with 348,412 annotated UTRSite motifs, 649,679 conserved elements and 105,209 experimentally validated miRNA targets.